Wegovy 0.25mg

Semaglutide (the active ingredient in Wegovy) has an elimination half-life of around 7 days, meaning half the drug leaves your body each week. After about 3 to 4 weeks, more than 90% of the medicine is cleared, with only small traces (around 3%) remaining by 5 weeks. Semaglutide is usually considered fully cleared within 6 to 7 weeks of the last dose.

No. Wegovy and Mounjaro contain different active ingredients, semaglutide and tirzepatide, so they work in slightly different ways. Both are the lowest starting doses in their treatment plans, but the doses are not directly equivalent.

If you are thinking about switching medications, this can be done under clinical guidance. Your clinician will recommend a starting dose tailored to your current medication, response and any side effects.

The 0.25mg dose is the starting dose, designed mainly to help your body adjust and reduce side effects. Some people notice appetite changes early on, but most will need a higher dose to see steady weight loss. While you’re building up to the dose that works best for you, you can also support results through your diet, activity and daily habits.

Usually for about four weeks, as part of the titration schedule. If you tolerate it well, you’ll move up until you reach the dose that works best for you.

Some people may choose to stay on 0.25mg for longer at the start to build tolerance if they are experiencing side effects, or if they already feel good appetite control and see steady weight loss.

Later, once you’ve reached your goal weight, you may step back down to 0.25mg for maintenance, provided it continues to control appetite safely.

Yes, but not for everyone in the same way. Appetite suppression, food noise control and early weight change vary from person to person at this dose. The main aim of 0.25mg is to help your body adjust and build tolerance for higher doses that deliver stronger results. You can support progress with diet, activity and routine while you titrate.

Learn ways to increase weight loss on Wegovy.

Wegovy follows a structured titration schedule, with the option to increase the dose every four weeks. Take one dose once a week and follow the schedule unless specifically advised otherwise by a clinician.

In clinical studies, people lost around 1–2% of their starting weight during the first few weeks on the 0.25mg dose. This early stage helps your body adjust to treatment, so most weight loss happens later as the dose increases.

No. The dose is increased gradually, starting at 0.25mg, then moving to 0.5mg, followed by 1mg and higher if needed.

Skipping doses or increasing too quickly can raise the risk of side effects.

Each Wegovy pen contains four doses, designed to be taken once a week.

Inject Wegovy once a week into the stomach, thigh or upper arm.

See our step-by-step injection guide.

Yes. If you are still adjusting or managing side effects, your clinician may keep you on this dose longer before increasing. Once it is well tolerated, you will usually move up to the next strength.

You can get Wegovy through regulated private providers like Voy or, in some cases, through NHS specialist weight-management services.

NHS eligibility is stricter and usually requires health problems related to weight and a higher BMI (often 35 or above). Lower BMI criteria may apply for some ethnic groups.