Wegovy 0.25mg Pen: Starting Dose

Yes. Wegovy 0.25mg is in stock at Voy with free next-day delivery. Once you complete your online assessment and a UK-registered prescriber approves your treatment, your pen is dispatched in discreet packaging.

Semaglutide (the active ingredient in Wegovy) has an elimination half-life of around 7 days, meaning half the drug leaves your body each week. After 3 to 4 weeks, more than 90% of the medicine is cleared, with only small traces (around 3%) remaining by 5 weeks. Semaglutide is usually considered fully cleared within 6 to 7 weeks of the last dose.

Most people stay on Wegovy 0.25mg for 4 weeks. If you tolerate it well, your dose will then increase to 0.5mg. Some people stay on 0.25mg longer, for example if side effects need more time to settle, or if appetite control and steady weight loss are already good at this dose.

After 0.5mg, the dose continues moving up gradually following the standard titration schedule. Skipping doses or jumping to a higher strength too quickly can increase the risk of side effects. The aim is to find your stable dose: the one with minimal side effects and the best results.

Yes, as long as it's still clinically appropriate and safe. After you reach your goal weight, you can stay on the dose you're on or gradually reduce until you find the dose that provides enough appetite suppression to keep your weight stable. This is your maintenance dose. For some people that's 0.25mg, for others it's a higher dose.

Whether 0.25mg is right for maintenance is a clinical decision your prescriber will make with you.

If you've missed one dose and it's been less than 5 days, take it as soon as possible, then continue with your usual weekly schedule.

If more than 5 days have passed, skip the missed dose and take your next dose on your usual day. Don't take two doses close together to make up for a missed one, as this can increase the risk of side effects.

If you've missed more than one dose, call our clinical hotline on 020 3912 9885 or message your clinical team in the Voy app. Your dose may need to be adjusted before you restart, depending on how long it's been since your last injection.

Each Wegovy 0.25mg pen contains four doses, one for each weekly injection. Inject Wegovy once a week into your stomach, thigh, or upper arm. See our step-by-step injection guide for the full process.

The Wegovy pen clicks as you turn the dial, but you don't need to count them. Turn the dial until 0.25 shows in the dose counter window, then inject once a week into your stomach, thigh, or upper arm.

If you're ever unsure your pen is dosing correctly, call our clinical team on 020 3912 9885 or message us in the Voy app.

Yes. From Mounjaro 2.5mg, your Wegovy starting dose will usually be either 0.25mg or 0.5mg, depending on how long it's been since your last Mounjaro injection and how well you've tolerated it.

Wegovy and Mounjaro contain different active ingredients (semaglutide and tirzepatide), so switching is done under clinical guidance. If you're already a Voy customer, you can start the switch in the Voy app by answering a short switching questionnaire. If you're switching from another provider, complete our online assessment so we can review your treatment history and recommend the right Wegovy starting dose for you.

Read more on switching between Mounjaro and Wegovy.

No. Wegovy is a once-weekly injection. Take one 0.25mg dose per week and follow the standard titration schedule. Doubling up doesn't speed up weight loss, and it can significantly increase the risk of side effects like nausea, vomiting, and stomach discomfort.

If you're unsure about your dose or schedule, call our clinical hotline on 020 3912 9885 or message your clinical team in the Voy app.