Treatments
Programme
Results
Experts
Resources
menu-close
WHAT WE TREAT
Weight loss
icon
Menopause
icon
ACCOUNT
Log in
icon
OVERVIEW
Weight loss overview
icon
TREATMENTS
Explore all options
Explore all options
icon
Mounjaro
Mounjaro
Lose up to 23% body weight
icon
Wegovy
Wegovy
Lose up to 21% body weight
icon
Saxenda
Saxenda
Lose up to 10% body weight
icon
Orlos
Orlos
Lose up to 8% body weight
icon
PROGRAMME
How it works
How it works
icon
Coaching
Coaching
icon
App
App
icon
ABOUT
Results
icon
Experts
icon
RESOURCES
Guides & tips
icon
ACCOUNT
Log in
icon
GET IN TOUCH
020 3912 9885
Mon-Fri 9:00-17:30
icon
OUR CLINIC
Menopause overview
icon
Pricing
icon
Clinicians
icon
TREATMENT PLANS
Hormone replacement therapy
icon
Testosterone treatment
icon
Cognitive behavioural therapy
icon
Vaginal treatments
icon
BLOOD TESTS
Women's midlife (MOT) blood test
icon
Monitor HRT blood test
icon
Start testosterone blood test
icon
WHAT WE TREAT
Skincare
New
icon
Perimenopause
icon
Menopause
icon
Sexual health
icon
Weight management
icon
LEARN
Guides
icon
Treatments
icon
ACCOUNT
Log in
icon
SUPPORT
FAQ
icon
Home/Guides & Tips/Weight loss/

Retatrutide vs Wegovy

Retatrutide vs Wegovy: What’s the difference?

Here’s what we know so far about how retatrutide compares to Wegovy.

clinician image

Medically reviewed by

Dr Earim Chaudry (MBBS), Chief Medical Officer

iconPublished 27th October 2025
Research-Based Guide
Table of contents
  • Is retatrutide better than Weg...
  • Retatrutide vs Wegovy
  • How is retatrutide different f...
  • How fast can you lose weight o...
  • Wegovy vs retatrutide: side ef...
  • Wegovy vs retatrutide: cost
  • How can you get Wegovy and ret...

They’re both weight loss injections that work by making you feel full. But retatrutide and Wegovy are quite different.

So, what sets them apart? Read on to find out.

Is retatrutide better than Wegovy?

First, a caveat: retatrutide isn’t approved yet, so a clinician can’t prescribe it to you.

However, based on the data we have so far, retatrutide appears to be very effective for weight loss. After 48 weeks, the average loss on retatrutide is 24.2% body weight.

Whereas, a 7.2mg dose of Wegovy led to an average loss of 20.7% after 72 weeks.

By the way: these results are from separate clinical trials, so we can’t really compare them directly. However, they can give us a sense of how well each medicine works.

Weight loss is a personal journey and there’s no single “best” medicine for it. There’s only what works for you. At Voy, our clinicians will work with you to create the perfect plan—whether that includes Wegovy weight loss injections or another medicine.

Don't wait to hit your health goals
Retatrutide isn’t available yet, but Wegovy and Mounjaro are already helping people lose weight. Start your journey today with proven treatments and support that sticks.
icon
Science backed programme
icon
Personalised support
icon
Trusted by 100k customers across the UK

Retatrutide vs Wegovy

Let’s take a closer look at how these two compare.

Features
Active ingredient
Manufacturer
Mechanism of action
How it’s taken
Weight loss results
Approved for use?
Wegovy
Semaglutide
Novo Nordisk
Mimics the hormone GLP-1
Weekly injection
20.7% after 72 weeks (7.2mg dose)
Yes. Available on NHS and via private prescription
Retatrutide
Retatrutide
Eli Lilly
Mimics GLP-1, GIP, and GCG
Weekly injection
24.2% after 48 weeks
No (expected 2026)

How is retatrutide different from Wegovy (semaglutide)?

The main thing that sets retatrutide and Wegovy apart is how they work.

Both mimic the effects of your body’s natural hormones to slow your digestion and keep cravings at bay.

But Wegovy only acts like one hormone, GLP-1. Whereas retatrutide mimics three: GLP-1, GIP, and GCG.

This triple action is why retatrutide is so potent.

You can also compare it with Ozempic in our guide: Retatrutide vs Ozempic.

How fast can you lose weight on retatrutide and Wegovy?

Everyone’s different, so we can’t say for sure how fast you’ll see results. But people on either medicine might notice their appetite start to curb within the first few weeks.

Wegovy vs retatrutide: side effects

Common symptoms are similar for both retatrutide and Wegovy:

  • Nausea
  • Diarrhoea
  • Vomiting
  • Constipation

This list isn’t exhaustive. Check in with your provider if you’re worried about side effects.

Side effects support at Voy

"If you're using Voy and you experience any side effects, rest assured that our expert clinicians are just a message or phone call away. They can adjust your dose, prescribe medication to ease your symptoms, or simply offer reassurance.

Everyone responds differently to weight loss treatment and we'll help you find what feels right for you."

Phoebe Fox - Weight Loss Specialist Clinician

Wegovy vs retatrutide: cost

We don’t know how much retatrutide will cost until it launches. But it will probably be priced similarly to Wegovy and Mounjaro weight loss injections. Prices can vary between private providers.

Whatever you do, make sure you’re buying from a registered provider. Otherwise, there’s no guarantee the products are genuine or safe to take.

How can you get Wegovy and retatrutide in the UK?

As a refresher: retatrutide isn’t available in the UK because it isn’t approved yet.

Wegovy is available on the NHS. But for now it’s limited to people who meet strict criteria and whose GP is part of the rollout.

If you don’t meet NHS criteria or want to explore treatment sooner, you may already be eligible through a private prescription—including through our weight loss programme. We’ll post you monthly weight loss medication and help you to transform your lifestyle, so you keep the weight off for good.

By the way: as well as Wegovy and other approved weight loss injections, we’ve got orlistat weight loss capsules, too.

Our Voy weight loss results speak for themselves: 94% say it’s the best weight loss programme they’ve tried. Take our quiz to see if you’re eligible.

Looking to start your weight loss journey?
Take a quick eligibility quiz to explore your options and see how we can support you.
FAQ

retatrutide vs wegovy: FAQ

Dr Earim Chaudry, MBBS
DisclaimerAt Voy, we ensure that everything you read in our blog is medically reviewed and approved. However, the information provided is not meant to replace professional medical advice, diagnosis, or treatment. It should not be relied upon for specific medical advice.
References
icon¹

“Wegovy: Information for the Patient.” Electronic Medicines Compendium, scribble-underlinewww.medicines.org.uk/emc/files/pil.13800.pdf Accessed 22 Oct. 2025.

icon²

Jastreboff, Ania M., et al. “Triple-hormone Receptor Agonist Retatrutide for Obesity—a Phase 2 Trial,” The New England Journal of Medicinescribble-underline, vol. 389, no. 6, 2023:514-526. www.nejm.org/doi/full/10.1056/NEJMoa2301972.

icon³

“Obesity - Treatment,” NHS,scribble-underline 2023 https://www.nhs.uk/conditions/obesity/treatment/. Accessed 22 Oct. 2025.

icon⁴

“Semaglutide for Managing Overweight and Obesity,” National Institute for Health and Care Excellence, scribble-underline2023 www.nice.org.uk/guidance/ta875/resources/semaglutide-for-managing-overweight-and-obesity-pdf-82613674831813. Accessed 22 Oct. 2025.

icon⁵

Wilding, John P.H., et al. “Once-weekly Semaglutide in Adults with Overweight or Obesity.” The New England Journal of Medicinescribble-underline, vol. 384, no. 11, 2021:989-1002 www.nejm.org/doi/full/10.1056/NEJMoa2032183.

Take the first step towards weight loss that lasts.

card-image
Weight Loss
Retatrutide vs Ozempic
Wondering how Ozempic shapes up to retatrutide? Here’s what to know.
card-image
Weight Loss
Where to buy retatrutide in the UK
You can’t legally buy retatrutide in the UK and it’s not safe to take just yet. Here’s how black-market sellers are exploiting legal loopholes.
card-image
Weight Loss
Is retatrutide safe?
Retatrutide isn’t approved just yet, but it’s driving impressive results for weight loss in clinical trials. Here’s what we know so far about its safety profile.
Have a question?
phone icon
020 3912 9885Monday - Friday 9am - 5pm
support icon
help@joinvoy.comWe aim to reply in 24hrs
email icon
press@joinvoy.comPress & media inquiries
Our services are not intended for use in a medical emergency. If you need urgent medical attention, please call 111 or 999.

Programme

  • How it works
  • Treatments
  • Coaching
  • The Voy App

Voy

  • Medical experts
  • Results

Legal

  • Privacy policy
  • Terms & Conditions
  • Terms of Sale
  • Complaints

Get help

  • Help Centre (FAQ)
facebooktwitterinstagram
Copyright 2025 Voy. All rights reserved.
Pharmacies: Manual PharmacySuperintendent Pharmacist: Vinisha KandaGPhC Registration: 2203475
registered pharmacycqc ratingcpd member