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Home/Guides & Tips/Testosterone/

Sustanon injections explained

TRT

Sustanon injections explained

Everything you need to know about Sustanon (or Sustanon 250), a type of testosterone replacement therapy injection.

clinician image

Medically reviewed by Medical Director

Dr. Jeff Foster - Men’s Health & TRT Specialist

iconUpdated 23 January 2026

All types of testosterone replacement therapy (TRT) work by upping your T levels. But they aren’t all the same. They’re each used differently and have their own pros and cons.

Here’s what to know about Sustanon injections.

Key Takeaways

  • What it is: Testosterone injection
  • How it’s used: Given directly into muscle roughly every 3 weeks
  • Who it’s for: Men with confirmed low testosterone
  • Pros: Releases T steadily
  • Cons: Only available as intramuscular injection
  • Availability: NHS or private prescription

What is Sustanon 250?

It’s a type of TRT injection. Sustanon (also called Sustanon 250) is a blend of four different synthetic versions of T, which are called testosterone esters.

Each ester is released into the body at a different rate. By taking all of them together, the idea is that you can combine these timelines to provide a fast initial release of T followed by a steadier release until your next injection (we’ve explained this in more detail below).

However, it doesn’t always pan out that way in practice. Sometimes, T drops off before the next injection is due—meaning men need to take their next dose sooner than the recommended three weeks.

What also sets Sustanon 250 apart is that its formula contains peanut oil. You shouldn’t use it if you’re allergic to peanuts or soy.

Sustanon injection: What it’s used for

Sustanon is a medicine for men with testosterone deficiency. Here, your low T levels need to be confirmed via blood test and a doctor’s assessment.

How does Sustanon work?

Like all types of TRT, Sustanon tops up testosterone and brings it into a healthy range. By combining four different testosterone esters, it provides a steady release of T until your next dose.

Here’s what that looks like. Initially, all four esters are present and releasing T (this is the early peak). Then, testosterone propionate is cleared from the body—it takes about 4-5 days to become undetectable in the blood. Meanwhile, testosterone phenylpropionate and isocaproate hang around for 8-11 days. And testosterone decanoate is detectable for 18 days. So, between injections, there’s at least one ester working to release testosterone.

Feeling drained and unfocused?
It might be low testosterone. Get answers fast with an at-home blood test.

Sustanon half-life and how long it lasts

The half-life of a medicine is the time it takes for half a dose to leave your system. After that point, its effects will start to dwindle.

On Sustanon 250, you’ll need to have an injection roughly every 21 days to keep your T levels steady.

How long does Sustanon stay in your system?

Generally, it takes four or five half-lives for a medicine to fully clear from your system.

Sustanon 250 has four active ingredients, so we’re dealing with four separate half-lives. Each ester will leave your body at a different rate. Overall, it might take a few months for Sustanon to completely flush out.

Sustanon side effects and safety considerations

Up to one in 10 people may experience:

  • Increase in red blood cell count
  • Weight gain

Other possible Sustanon side effects include:

  • Itching
  • Acne
  • Nausea
  • Muscle pain
  • Fluid retention

Get in touch with your provider if your symptoms get worse or don’t go away.

Sustanon vs other TRT treatments

Here’s how Sustanon compares to other types of TRT.

Cypionate vs Sustanon

We usually recommend testosterone cypionate over Sustanon because it’s less painful to use (since you can inject it under the skin vs into muscle). It’s made with cottonseed or olive oil.

Sustanon vs enanthate

Testosterone enanthate is very similar to cypionate. The main difference between enanthate and cypionate is the carrier oil: enanthate is made with sesame oil. That means it may be harder to inject—and therefore might be more likely to cause injection site reactions.

Nebido vs Sustanon

Nebido is injected directly into the muscle, but it takes much longer to leave your system than Sustanon. You take Nebido every 10 to 14 weeks.

With Nebido, there can sometimes be peaks and troughs in T levels between doses.

How to inject Sustanon

Sustanon is injected straight into the muscle, usually in your bottom or thigh.

Once you’ve started Sustanon, a follow-up blood test at the 3, 6, and 12-month mark is recommended to monitor your progress. After that, you’ll get tested every 6 months.

How often to inject Sustanon

The typical dose is one injection of 1ml Sustanon every three weeks.

At Voy, we’ll personalise your dosing schedule depending on how you’re responding to the medicine.

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Buying Sustanon in the UK

You need a prescription to get Sustanon in the UK.

If you want to buy Sustanon from a private provider, make sure they’re registered and that you’re working with qualified clinicians. For pharmacies, that means being registered with GPhC, while clinics should be registered with the CQC. This information should be on their website.

Otherwise, there’s no guarantee that the products are safe or genuine.

Good to know: you can get Sustanon online from a registered, qualified provider (like us!).

Alternative to Sustanon

But Sustanon may not always be best for you personally.

For example, it can affect fertility by suppressing your natural T production. So, if you are planning to have kids in the future, treatments like hCG or Clomid may be recommended instead.

If you’re allergic to peanuts or soy, testosterone cypionate is usually suggested as an alternative to Sustanon.

And finally, if needles aren’t your thing, there are testosterone gels and creams you could try.

We can create a personalised treatment plan to get your T back within a healthy range. With Voy, 90% of men have improved symptoms within 3 months.

Take a testosterone blood test to get started.

FAQ

FAQs about Sustanon injections

Continue reading

  • Male menopause (andropause)
  • Benefits of testosterone replacement therapy
  • Testosterone gel for men
  • Enclomiphene citrate
  • Once you start testosterone therapy, can you stop?
  • Is testosterone a steroid?
  • High testosterone in men
  • Oestradiol levels in men
  • Foods that increase testosterone
  • Does testosterone make you stronger?
  • Does testosterone make you lose weight?
  • Does masturbation decrease testosterone?
  • Does ashwagandha increase testosterone?
  • Does nicotine increase testosterone?
  • TRT cost in the UK
  • Men’s health stigma around low testosterone
  • Does testosterone cause hair loss?
  • What is tadalafil?
  • Anadrol (oxymetholone)
DisclaimerAt Voy, we ensure that everything you read in our blog is medically reviewed and approved. However, the information provided is not meant to replace professional medical advice, diagnosis, or treatment. It should not be relied upon for specific medical advice.
References
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Abouelmagd, Alaa Abdrabou, et al. “Efficacy and Safety of Retatrutide, a Novel GLP-1, GIP, and Glucagon Receptor Agonist for Obesity Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Proceedings (Baylor University. Medical Center)scribble-underline, vol. 38, no. 3, 2025, pp. 291–303. https://pmc.ncbi.nlm.nih.gov/articles/PMC12026077/

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Jastreboff, Ania M., et al. “Body Composition Changes with Retatrutide in Adults with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial.” The Lancet Diabetes & Endocrinologyscribble-underline, vol. 15, 2025, pp. 112–123. https://www.sciencedirect.com/science/article/abs/pii/S2213858725000920.

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Jastreboff, Ania M., et al. “Triple–Hormone-Receptor Agonist Retatrutide for Obesity.” The New England Journal of Medicinescribble-underline, vol. 389, no. 6, 2023, pp. 514–526. https://pubmed.ncbi.nlm.nih.gov/37366315/

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Rosenstock, Julio, et al. “Retatrutide, a GIP, GLP-1 and Glucagon Receptor Agonist, for People with Type 2 Diabetes: A Randomised, Double-Blind, Placebo and Active-Controlled, Parallel-Group, Phase 2 Trial Conducted in the USA.” The Lancetscribble-underline, vol. 402, no. 10401, 2023, pp. 529–544. https://pubmed.ncbi.nlm.nih.gov/37385280/

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U.S. National Library of Medicine. “A Study of Retatrutide (LY3437943) in Participants with Obesity or Overweight (TRIUMPH-1) (NCT05929066).” ClinicalTrials.govscribble-underline. https://clinicaltrials.gov/study/NCT05929066. Accessed 3 Nov. 2025.

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U.S. National Library of Medicine. “A Study of Retatrutide (LY3437943) in Participants with Obesity (Maintenance of Weight Loss) (NCT06859268).” ClinicalTrials.govscribble-underline. https://clinicaltrials.gov/study/NCT06859268. Accessed 3 Nov. 2025.

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Zheng, Z., et al. “Glucagon-Like Peptide-1 Receptor: Mechanisms and Advances in Therapy.” Signal Transduction and Targeted Therapyscribble-underline, 2024. https://www.nature.com/articles/s41392-024-01931-z

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