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Menopause
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Treatment information

Utrogestan

Utrogestan is a micronised progesterone which should be taken alongside oestrogen as part of combined HRT, if you still have a womb.

Over time, if you take oestrogen alone, without a progestogen, the lining of the womb can get too thick, which can cause problems. Utrogestan contains progesterone, which provides endometrial protection and prevents these problems, as it makes you shed the womb lining.

Because of this, you might get some bleeding at the end of each cycle.

iconUpdated 28 May 2026
iconMedically reviewed by Katy Jackson, Clinical Director - Women's Health

What is Utrogestan?

Utrogestan is a body-identical progesterone used in hormone replacement therapy (HRT) for individuals who still have a womb. It is made from plant sources and is chemically identical to the progesterone your body naturally produces.

When you take oestrogen as part of HRT, it can cause the lining of the womb (endometrium) to thicken. Utrogestan balances this effect, helping to keep the lining healthy and reducing the risk of endometrial cancer.

Utrogestan is usually prescribed alongside oestrogen in either a cyclical (monthly) or continuous (daily) regimen, depending on your stage of menopause. If you've had a hysterectomy, you typically won't need it.

Benefits of Utrogestan

Utrogestan is part of the body-identical HRT group, meaning it matches the hormones your body naturally produces. It's often preferred over synthetic progestogens for several reasons:

  • Body-identical and plant-derived, making it a more natural option
  • Fewer side effects for many women compared to synthetic progestogens
  • May improve sleep quality, especially when taken at night
  • Less likely to affect mood, with some women reporting a calming effect
  • Well tolerated, even by those who have struggled with other types of HRT
1 Balances oestrogen
2 Protects womb lining
3 Reduces menopause symptoms
4 Supports better sleep
5 Supports mood stability
6 Generally well tolerated

How to safely use Utrogestan

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Instructions for use

Side effects of Utrogestan

The most common side effects associated with Utrogestan are changes to your monthly bleeding pattern. Some patients also experience headaches, bloating and mood changes, especially when first starting treatment.

Understanding Utrogestan

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Remember that finding the right HRT approach sometimes takes adjustment. Our clinicians are here to support you throughout your menopause journey, with regular reviews to ensure your treatment continues to work well for you.

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iconThis page is provided for reference purposes only. Always follow the advice and guidance of your prescribing doctor regarding your medication and prescriptions. Do not make any changes to your medication regimen without consulting your healthcare provider.

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