Utrogestan

Utrogestan comes in 100 mg capsules and is taken orally at bedtime, ideally on an empty stomach (at least 2 hours after eating) to maximise absorption.

Your dosage depends on whether you’re using a cyclical or continuous HRT regimen:

Cyclical (Sequential) Regimen

Used if you are still having periods or it’s been less than 12 months since your last period:

• Take 200 mg (two capsules) at bedtime for 12 days each month, usually days 15 to 26 of your cycle
• This typically results in a monthly withdrawal bleed

Continuous Regimen

Used if you are postmenopausal (no periods for 12+ months):

• Take 100 mg (one capsule) every night for 25 days of a 28-day cycle (or as prescribed)
• This aims to prevent monthly bleeding

• Swallow whole with water, do not crush or chew
• Take at bedtime to reduce side effects like drowsiness
• Avoid eating for at least 2 hours before taking

Utrogestan is generally well tolerated, particularly compared to synthetic progestogens. However, as with all HRT, side effects can occur, especially during the adjustment period.

Common side effects include:

• Drowsiness or dizziness, especially if taken too soon after eating
• Breast tenderness or bloating
• Mood changes, though often less severe than with synthetic progestogens
• Breakthrough bleeding or spotting, particularly in the first 3–6 months

These often improve with time. If they persist or become disruptive, speak to your clinician—there may be an alternative dosing schedule or formulation that suits you better.

Rare but serious side effects (such as allergic reactions or blood clots) are uncommon but should be treated as urgent. Contact a healthcare professional if you experience chest pain, leg swelling, or breathing difficulties.